Fikret Türkan

Fikret Türkan

Dr. Öğr. Üyesi

Telefon:04762230010

E-mail:fikret.turkan@igdir.edu.tr

Akademik Birim
:
Sağlık Hizmetleri Meslek Yüksekokulu
Bölüm
:
Tıbbi Hizmetler ve Teknikler
Anabilim Dalı/Program
:
Kimya/Biyokimya
İdari Görevler
:
Lisans
:
Yüzüncü Yıl Üniversitesi-2004
Yüksek Lisans
:
Yüzüncü Yıl Üniversitesi-2009
Doktora
:
Atatürk Üniversitesi-2015
Diller
:
İngilizce
İlgi Alanları
:
Enzim saflaştırma, Enzim Kinetiği, Enzim inhibisyonu, Elektroforez, Protein tayini, Spektrofotometrik tayin metodları
Uluslararası hakemli dergilerde yayımlanan makaleler:

1.Gülçin, İ.Scozzafava, A., Supuran C.T., Koksal, Z.,Turkan, F., Çetinkaya, S., Bingöl, Z.,Huyut, Z., Alwasel, S. H. 2016. "Rosmarinic acid inhibits some metabolic enzymes including glutathione S-transferase, lactoperoxidase, acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase isoenzymes" Journal of Enzyme Inhibition and Medicinal Chemistry, 31:6, 1698-1702.

2. Gülçin, İ.Scozzafava, A., Supuran C.T., Akıncıoğlu, H., Koksal, Z.,Turkan, F., Alwasel, S. H. 2015.The effect of caffeic acid phenethyl ester (CAPE) on metabolic enzymes including acetylcholinesterase, butyrylcholinesterase, glutathione S-transferase, lactoperoxidase, and carbonic anhydrase isoenzymes I, II, IX, and XII. Journal of Enzyme Inhibition and Medicinal Chemistry, 31:6, 1095-1101

3. Taslimi, P., Çağlayan, C., Farzaliyev, V., Nabiyev, O., Sujayev, A., Turkan, F., Kaya, R., Gulçin, İ. (2018).  Synthesis and discovery of potent carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase and α- glycosidase enzymes inhibitors: the novel N,N′-bis-cyanomethylamine and alkoxymethylamine derivatives. Journal of Biochemical and Molecular Toxicology, 2018, 32(4), e22042.

4. Taslimi, P., Sujayev, E., Turkan, F., Garibov, E., Huyut, Z., Farzaliyev, F., Mamedova, S., Gulçin, İ. (2018). Synthesis and investigation of the conversion reactions of pyrimidine-thiones with nucleophilic reagent and evaluation of their acetylcholinesterase, carbonic anhydrase inhibition and antioxidant activities. Journal of Biochemical and Molecular Toxicology, 2018, 32(2), e22019.

5. Turkan, F., Huyut, Z., Taslimi, P., Gulçin, İ., (2018). The effects of some antibiotics from cephalosporin groups on the acetylcholinesterase and butyrylcholinesterase enzymes activities in different tissues of rats. Archives of Physiology and Biochemistry, https://doi.org/doi:10.1080/13813455.2018.1427766

6. Turkan, F., Huyut, Z., Taslimi, P., Gulçin, İ. (2018). The in vivo effects of cefazolin, cefuroxime, and cefoperazon on the carbonic anhydrase in different rat tissues. Journal of Biochemical and Molecular Toxicology, 32(3), e22041. 

7. Turkan, F., Huyut, Z., Demir, Y., Ertaş, F., Beydemir, S. (2018). The effects of some cephalosporins on acetylcholinesterase and glutathione S-transferase: an in vivo and in vitro study. Archives of Physiology and Biochemistry, https://doi.org/doi:10.1080/13813455.2018.1452037

8. Aslan, H.E., Demir, Y., Özaslan, M.S., Türkan, F., Beydemir, S., Küfrevioğlu, O.I. (2018). The behavior of some chalcones on acetylcholinesterase and carbonic anhydrase activity. Drug and Chemical Toxicology, https://doi.org/10.1080/01480545.2018.1463242

9. Abdulmelik Aras, Bursal, Ercan., Alan, Y., Turkan, F., Alkan, H., Kilic, (2018). Polyphenolic composition, antioxidant potential and antimicrobial activity of Satureja boissieri. Iranian Journal of Chemistry and Chemical Engineering (IJCCE). 37. 

10. Turkan, F., Huyut, Z., Taslimi, P., Huyut,  M.T., Gulcin, İ. (2018). Investigation of the Effects of Cephalosporin Antibiotics on Glutathione S-transferase activity in Different Tissues of Rats in Vivo Conditions in Order to Drug Development Research.  Drug and Chemical Toxicology, https://doi.org/10.1080/01480545.2018.1497644

11. Turkan, F., Huyut, Z., Atalar M.N. (2018). The toxicological impact of some avermectins on glutathione S-transferase enzyme. Journal of Biochemical and Molecular Toxicology, DOI: 10.1002/jbt.22205

12. Taslimi, P., Osmanova, S.,  Çağlayan, C., Turkan, F., Sardarova, S.,  Farzaliyev, V.,  Sujayev, A., Sadeghian, N., Gulçin, İ. (2018). Novel Amides of 1,1-Bis-(Carboxymethylthio)-1-Arylethanes: Synthesis, Characterization, and Acetylcholinesterase, Butyrylcholinesterase, and Carbonic Anhydrase Inhibitory Properties. Journal of Biochemical and Molecular Toxicology, DOI: 10.1002/jbt.22191

13. Gondolova, G., Taslimi, P., Medjidov, A., farzaliyev, V., Sujayev, A., Mansura, H., Sahin, O., Yalçın, B., Turkan, F., Gulçin, I. (2018). Synthesis, Crystal Structure and Biological Evaluation of Spectroscopic Characterization of Ni(II) and Co(II) Complexes with N-Salicyloil-N’-Maleoil- Hydrazine as Anticholinergic and Antidiabetic Agents. Journal of Biochemical and Molecular Toxicology,https://doi.org/10.1002/jbt.22197

14. Gülçin, İ., Taslimi, P., Aygün, A., Sadeghiana, N., Bastem, E., Küfrevioglu, O.I., Türkan, F., Sen, F. (2018). Antidiabetic and antiparasitic potentials: Inhibition effects of some natural antioxidant compounds on α-glycosidase, α-amylase and human glutathione S-transferase enzymes, International Journal of Biological Macromolecules, 119,741-746.

15.Türkan, F., Çetin, A., Taslimi, P., Gulçin, I. (2018). Some Pyrazoles Derivatives: Potent Carbonic Anhydrase, α-Glycosidase and Cholinesterase Enzymes Inhibitors.  Archiv der PharmazieDOI: 10.1002/ardp.201800200

16. Cetin, A., Türkan, F., Taslimi, P., Gülçin, İ. (2018). Synthesis and Characterization of Novel Substituted Thiophene Derivatives and Discovery of Their Carbonic Anhydrase and Acetylcholinesterase Inhibition Effects. Journal of Biochemical and Molecular Toxicology, DOI: 10.1002/jbt.22261

17.Fikret Türkan, Halit Demir, (2018). Purification and Characterization of Polyphenol Oxidase Enzyme from Igdır Apple and Inhibition Effects of Some Chemicals. International Journal of Science and Research. 7(10), 829-832.    

18. Turkan, F., Çetin, A., Taslimi, P., Karaman M., Gulçin, I. (2019). Synthesis, Biological Evaluation and Molecular Docking of Novel Pyrazole Derivatives as Potent Carbonic Anhydrase and Acetylcholinesterase Inhibitors. Bioorganic Chemistry, 86 (2019), 420-427.

 

 

Ulusal hakemli dergilerde yayımlanan makaleler:

1. Turkan F, Balcı N, Şakiroğlu H, 2014. Purification and characterization of glutathione s- ransferase from laurel fruit (laurocerasus officinalis roem.) And inhibition the effects of some pesticides on enzyme activity. Muş Alparslan University Journal of Science, 2(2):280-288.

2. Turkan F, Atalar M.N. 2018. The Effects of Amoxicillin and Vancomycin Hydrochloride Hydrateon Glutathione S-Transferase Enzyme Activity: An in vitro study. Iğdır University Journal of the Institute of Science and Technology, 8(2): 141-148

3. Atalar M.N., Turkan F2018. Identification of Essential Oil from the Rhizomes of Acorus Calamus L.by Using Gas Chromatography/Mass Spectrometry(GC-MS/MS). Iğdır University Journal of the Institute of Science and Technology, 8(4): 181-187.

Uluslararası bilimsel toplantılarda sunulan ve bildiri kitaplarında (proceedings) basılan bildiriler:

 1.Fikret Turkan. Investigation of the Inhibition Effects of Essitalopram and Mirtazapine on Glutathione S-Transferase and Acetylcholinesterase Enzymes. MAS 3. Uluslararası Avrupa Fen- Matematik- Mühendislik ve Sağlık Bilimleri Kongresi, 2-3 Şubat 2019.(Oral  presentation), ŞANLIURFA/TURKEY

2. Fikret Türkan, Zübeyir Huyut, Mehmet Nuri Atalar. Investigation of the inhibition effects of some avermectin varieties on glutathione S-transferase enzyme. "1st Internatıonal Balkan Chemıstry Congress." September 17-20, 2018.(Oral  presentation) Edirne/Turkey.

3. Fikret Türkan, Mehmet Harbi Çalımlı, Ayhan Akgün. Yeni GST İnhibitörleri Olarak Bazı Benzimidazoller. "IĞDIR INTERNATIONAL CONFERENCE ON  MULTIDISCIPLINARY STUDIES". November 6-7, 2018.(Oral  presentation) Iğdır/Turkey.

4. Fikret Türkan, Parham Taslimi, Fatma Zerrin Saltan, Inhibitory Effect of Tannic Acid on Acetylcholinesterase, Butyrylcholinesterase, α‐Glycosidase and α‐Amylase Enzymes, INTERNATIONAL SYMPOSIUM ON “NATURAL PRODUCTS IN CANCER PREVENTION AND THERAPY. 4-7 September 2018,(Oral Presentation) Napoli/ Italya.

5. Fikret Türkan, Zübeyir Huyut, Inhibition behaviour of some antibiotics on glutathione S-transferase and acetyl cholinesterase  ctivities: in vitro and in vivo. 7th World Congress of Oxidative Stress, Calcium Signaling and TRP Channels, 20 - 23 April 2018 Alanya / Antalya / TURKEY. (Oral Presentation)

6. Fikret Türkan, Zübeyir Huyut, In Vivo Effects of Cefazolin, Cefuroxime, and Cefoperazon on the Carbonic Anhydrase Activity in Different Rat Tissues, Time Dependently, 1st INTERNATIONAL HEALTH SCIENCE AND LIFE CONGRESS 02-05 May 2018, Burdur / TURKEY. (Oral Presentation)

7. Fikret Türkan, Zübeyir Huyut, Parham Taslimi,ACTIONS OF SELECTED ANTIBIOTICS FROM CEPHALOSPORIN GROUPS ON THE ACETYLCHOLINESTERASE AND BUTYRYLCHOLINESTERASE ENZYMES ACTIVITIES IN DIFFERENT TISSUES OF RATS TIME- EPENDENTLY: IN VIVO STUDY, 1st International Veterinary Biochemistry and Clinical Biochemistry Congress, 12-15 April, 2018, Hatay, Turkey. (Oral Presentation)

8. Servet Aşkın, Fikret Türkan, "Raman Spectrum and Quantıtatıve Ratıo of Ararat Volcanıc Mountaın’s Basaltıc Rocks and Albıte Mıneral" II Internatıonal Scıentıfıc and Vocatıonal Studıes Congress (BILMES 2018), 5-8  July 2018,(Oral Presentation), Nevşehir/ Turkey.

9. Fikret Türkan, Zübeyir Huyut, Parham Taslimi, Mehmet Tahir Huyut, İlhami Gülçin, Effect of Some Antıbıotıcs on Glutathıone-S-Transferase Activity in Kidney, Heart and Liver Tissues, Uluslararası Biyokimya Kongresi, Erzurum, Türkiye 19-23 Eylül-2017.(Oral Presentation)

10. Fikret Türkan , Halit Demir, The Effect Of Some Chemical Compounds On The Poliphenol Oxidase (PPO) Enzyme Activity Isolated From The Iğdır Apple, II. International Iğdır Symposium, Iğdır, Türkiye, 9-11 October 2017.(Oral Presentation)

11. Fikret TÜRKAN, The effects of amoxicillin and vancomycin hydrochloride hydrate on glutathione S- transferase enzyme activity (GST, E.C.2.5.1.18),International Turkish World Conference on Chemical Sciences and Technologies (ITWCCST), Skopje, Macedonia on October 26-30, 2016(Oral Presentation)  

12. BALCI Neslihan,TÜRKAN Fikret ,SAKIROGLU Halis, Researchıng Of the Inhıbıtıon Of Some Metal Ions Glutathıone S-Transferase (GST) Enzyme Actıvıty to the Isolated From Blueberry (Vaccinium Arctostaphylos L.) International Turkish World Conference on Chemical Sciences and Technologies (ITWCCST), Skopje Macedonia on October 26-30,2016.  (Poster Presentation) 

13. Türkan F., Balcı N., Şakiroğlu H. "Purification and Characterization of Glutathione S-transferase From Laurel Fruit (Prunus Laurucerasus L.) Research The Effects of Some Metal Ions on Enzyme Activity". International Turkish World Conference on Chemical Sciences and Technologies (ITWCCST)27-1 October 2015- Sarajevo.(Poster Presentation) 

14. Türkan F., Balcı N., Şakiroğlu H. Purification and Characterization of Glutathione S-transferase From Laurel Fruit (Prunus Laurucerasus L.) Research The Effects of Some Pesticides on Enzyme Activity. International Congress of the Molecular Biology Association. 10-12 September 2014- İzmir/Turkey.(Poster Presentation) 

 
Ulusal bilimsel toplantılarda sunulan ve bildiri kitaplarında (proceedings) basılan bildiriler:

1. Balcı N., Türkan F., Şakiroğlu H. Yaban mersini meyvesinden (Vaccinium myrtillus) saflaştırılan Glutatyon S-transferaz enzim aktivitesi üzerine bazı kimyasalların inhibisyon etkilerinin incelenmesi. 27. Ulısal Kimya Kongresi, 23-28 Ağustos 2015, Çanakkale

2. Türkan F., Balcı N., Şakiroğlu H. Purification and Characterization of Glutathione S-Transferase from Laurel Fruit (Laurucerasus Officinalis Roem.) and Inhibition the Effects of Some Organic Compounds on Enzyme Activity. 15th Chromatography Congress, 8-10 April 2015, Uşak

3. Türkan F., Demir H. The Investigation of some characteristicts and prufication of polyphenol oxidase enzyme from ığdır apple. 10th Chromatography Congress, 2010, Erzurum

Yazılan ulusal / uluslararası kitaplar:
Yazılan ulusal / uluslararası kitaplardaki bölümler:
Diğer Yayınlar:
Yönetilen Doktora Tezleri:
Yönetilen Yüksek Lisans Tezleri:
Projeler:

1. Bazı Antibiyotiklerin Glutatyon S-Transferaz ve Asetilkolin Esteraz Enzim Aktiviteleri Üzerine İn vitro ve İn vivo İnhibisyon Etkilerinin Belirlenmesi. Iğdır Üniversitesi 2016-SBE-B08 numaralı BAP Projesi (Yürütücü)- sonuçlandı.

2.Ağrı Dağı volkanik kayaçlarının yeraltı ve yerüstü sularına etkisi. 2016-FBE-04 numaralı BAP projesi (Araştırmacı)- sonuçlandı.

3. Sefazolin, Sefuroksim ve Sefaperazon ilaçlarının karaciğer, böbrek ve beyin dokularında lipid peroksidasyonu ve bazı antioksidan enzim aktivitelerine etkilerinin incelenmesi. Iğdır Üniversitesi 2017-SBE-A11 numaralı BAP Projesi (Yürütücü)- sonuçlandı.

4. Yeni Sentezlenen 1H-Pirazol-4- (5H) -il Diazen Türevlerinin Glutatyon S-transferaz, Asetilkolin esteraz, Bütirilkolin esteraz ve α- Glukozidaz Enzimleri Üzerine İnhibisyon Etkilerinin İncelenmesi. Iğdır Üniversitesi 2018-SBE-A01 numaralı BAP Projesi (Yürütücü)- sonuçlandı.

5. Doksorubisin ile indüklenen Testis Yaralanmasında Kaffeik Asit Fenetil Ester ve Kurkuminin Koruyucu Etkilerinin Karşılaştırılması-Yüzüncü Yıl Üniversitesi BAP Projesi (Araştırmacı)- devam ediyor.

6. Diyabetik nefropatisi olan hastalarda metil arjinin düzeylerinin değerlendirilmesi(araştırmacı)-devam ediyor

Hakemlikler:

1. Journal of The Institute of Science and Technology, Igdir University

2.  Hacettepe Journal of Biology and Chemistry, Hacettepe University

3. Journal of The Institute of Science and Technology, Van Yüzüncü Yıl University

Verilen Dersler:

Genel Kimya

Laboratuvar Kimyası

Biyokimya

Klinik Biyokimya

Hormon Biyokimyası

İleri Biyokimya- Yüksek Lisans

Biyokimya Laboratuvar Uygulamaları- Yüksek Lisans

Temel Laboratuvar Uygulamaları I

Temel Laboratuvar Uygulamaları II

Ödüller:
Üyelikler:
Harici Tel.
:
04762230010
Dahili Tel.
:
3130
Belgegeçer
:
E-posta
:
fikret.turkan@igdir.edu.tr
Web Site
:
Adres
:
Iğdır Üniversitesi, Karaağaç Kampüsü Sağlık Hizmetleri MYO Kat:4, No:19